Activation pattern in the prefrontal system of kainic acid-pretreated rats.

The aim of the present experiment was to find out whether lesions in the prefrontal system, produced with kainic acid (KA) would disrupt the pattern of activation of the prefrontal system, determined by the deoxyglucose technique. The activation was induced by injections of penicillin into the prefrontal cortex. There was no difference between the pattern previously described in rats with intact brains and that seen in the present animals pretreated with kainic acid. Thus, the doses of KA which destroy some neurons in the prefrontal system do not interfere with the spread of epileptic activity throughout this system.